Sailing the Moselle River provides a charming and scenic river cruise experience, offering a unique blend of natural beauty, historic landmarks, and renowned wine regions. The region is particularly known for its white wines, with Riesling being the most famous grape variety grown along the Moselle. The steep slopes of the river valley provide excellent conditions for grape cultivation. Dotted with charming towns and villages that have preserved their medieval charm, places such as Cochem, Bernkastel-Kues, and Trier offer an opportunity to explore cobblestone streets, half-timbered houses, and historic landmarks. The region is also home to numerous castles, such as the majestic Burg Eltz, which adds a fairytale-like quality to the landscape.

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The Moselle River, known as Mosel in German, is a river that flows through France, Luxembourg, and Germany. It is approximately 544 kilometers (338 miles) long. The Moselle River is one of the major tributaries of the Rhine River. Its confluence with the Rhine near Koblenz forms an important waterway junction in Germany.​ The source of the Moselle River is located in the Vosges Mountains of northeastern France. Specifically, near the village of Bussang in the department of Vosges. Its source is at an elevation of about 715 meters (2,346 feet) above sea level.

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The Moselle River has a rich history dating back to Roman times. Several Roman ruins and archaeological sites can be found along its course, reflecting the region's historical importance and the Roman presence in the area. The Moselle River is dotted with numerous castles, some of which are open to the public and offer panoramic views of the river and the surrounding countryside.

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All Moselle River cruise itineraries will be combined with some portion of the Rhine River.